Human chorionic gonadotrophin: comparative studies of ovarian uptake in mammals.
نویسنده
چکیده
-l. The localization of radiolabeled human chorionic gonadotrophin (~2SI-HCG) was studied in a number of commonly used mammalian animal models. 2. The ovary proved to be the target organ for ~25I-HCG in all animals studied. 3. The optimum time for the localization of HCG in the ovary varied in all the mammals extending from 1.5 to 4 hr. 4. HCG is apparently used in the target cell for only a brief period and is excreted rapidly as indicated by renal uptake levels. 5. All other female organs and tissues failed to display any affinity for HCG. 6. The affinity of 125I-HCG for the various mammalian ovaries studied occurred in the following sequence: rat > mouse > guinea pig > hamster > monkey.
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ورودعنوان ژورنال:
- Comparative biochemistry and physiology. A, Comparative physiology
دوره 52 1 شماره
صفحات -
تاریخ انتشار 1975